WebJun 15, 2024 · DNA-protein crosslinks (DPCs) are deleterious DNA lesions that occur when proteins are irreversibly covalently crosslinked to the DNA by the action of variety … WebThe nucleotide excision repair (NER) process typically removes bulky abnormalities caused by chemicals or radiation (often called lesions) by cutting out the damaged region of DNA. For example, NER protein XPA …
ACRC/GCNA is an essential protease for the repair of DNA-protein ...
WebAug 4, 2024 · Proteins acting on or residing in proximity to DNA can become covalently trapped, giving rise to DNA-protein crosslinks (DPCs). These bulky lesions can undermine the integrity and functionality of the genome, as DPCs interfere with essential DNA-associated transactions including DNA replication and transcription. WebMar 1, 2013 · Many bifunctional alkylating agents and anticancer drugs exert their cytotoxicity by producing cross links between the two complementary strands of DNA, termed interstrand crosslinks (ICLs). This blocks the strand separating processes during DNA replication and transcription, which can lead to cell cycle arrest and apoptosis. metallic midnight sapphire blue
Frontiers DNA-Histone Cross-Links: Formation and Repair
WebProtein Crosslinks Bulky Dna Lesions AbstractProteins covalently attached to DNA, also known as DNA–protein crosslinks (DPCs), are common and bulky DNA lesions that interfere with DNA replication, repair, transcription and recombination. WebOct 31, 2024 · DNA interstrand crosslinks (ICLs) are lesions that covalently link opposing strands of the double helix. ICLs physically block cellular processes that require the unwinding of the DNA molecule, such as replication, recombination, and transcription. WebNER removes bulky lesions formed by UV light, environmental mutagens and chemotherapeutic agents from DNA. Defects in NER lead to the inherited disorder xeroderma pigmentosum, which is characterized by extreme UV sensitivity and predisposition to skin cancer. how thick is .375