Web17 apr. 2024 · LCMV, which is part of the Arenaviridae family, is a well-established mouse model for acute and chronic virus infections, and it has allowed the identification of many immunological principles that were subsequently confirmed in human infections, such as CTL escape or CD8 T cell exhaustion. Web15 jun. 2024 · T cell exhaustion and successful therapy to restore T cell function initially uncovered with lymphocytic choriomeningitis virus (LCMV) Clone (Cl) 13 infection is …
Frontiers Disruption of IL-33 Signaling Limits Early CD8+ T Cell ...
Web9 jan. 2024 · LCMV Arm sets up an acute infection in mice that is cleared resulting in functional memory CD8 + T cells. On the other hand, LCMV Cl-13 sets up a chronic infection that generates GP33 +... Web16 jun. 2011 · Unc13djinx/jinx mutants infected with lymphochoriomeningitis virus (LCMV) present typical clinical features of HLH, including splenomegaly, elevated serum IFNγ, and anemia. Proteins mediating cell-cell contact, cytokine signaling or Toll-like receptor (TLR) signaling were analyzed. inhibition mitochondrial pyruvate transport
Dynamics of CD8 T Cell Responses during Acute and Chronic …
Web1 nov. 2011 · LCMV infection of its natural reservoir host, the mouse, can vary widely depending on the age and strain of the mouse and the dose, strain and infection-route … WebLymphocytic choriomeningitis, or LCM, is a rodent-borne viral infectious disease caused by lymphocytic choriomeningitis virus (LCMV), a member of the family Arenaviridae, that … Web7 apr. 2003 · A mathematical model quantitatively integrating the virus distribution kinetics in the host, the specific cytotoxic T lymphocyte (CTL) response in spleen and the re … mlb the show early release date