Witryna26 mar 2013 · Major functional clusters for Up-Ex RAGs were glycosaminoglycan binding, cell migration, inorganic cation hemostasis, regulation of phosphorylation, regulation of apoptosis. Down-Nd RAGs were found in the clusters annotated as calcium binding region, domain EF hand, and mitosis. Witryna2 kwi 2014 · The world is getting more complex and interconnected. Increasingly, problem-solving requires knowledge and skills from different expertises. Correspondingly, computational sciences, in particular machine learning and big-data analytic have been rapidly developing to accommodate the need to comprehend operations and …
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Witryna14 lip 2006 · Carnitine is a zwitterion essential for the {beta}-oxidation of fatty acids. We report novel localization of the organic cation/carnitine transporter, OCTN1, to mitochondria. We made GFP- and RFP-human OCTN1 cDNA constructs and showed expression of hOCTN1 in several transfected mammalian cell lines. Witryna8 godz. temu · Organic cation transporter 2 (OCT2) is mainly responsible for the renal secretion of various cationic drugs, closely associated with drug-induced acute kidney injury (AKI). Screening and identifying potent OCT2 inhibitors with little toxicity in natural products in reducing OCT2-mediated AKI is of great value. Flavonoids are enriched in … epinephrine effect on alpha 2 receptors
Different Involvement of Promoter Methylation in the Expression …
WitrynaThe high-affinity OCTN2 (SLC22A5 gene) carnitine transporter plays a key role in a carnitine homeostasis [4, 10]. It is highly ex-pressed in the heart, muscle and kidney and operate a sodium-de-pendent transport of carnitine and a sodium-independent organic cation transport. A defect in the OCTN2 carnitine transporter cause primary … WitrynaReferences: Amat di San Filippo C et al. Tyrosine residues affecting sodium stimulation of carnitine transport in the OCTN2 carnitine/organic cation transporter. J Biol Chem. 2004; 279(8):7247-53. Li F et al. Molecular spectrum of SLC22A5 (OCTN2) gene mutations detected in 143 subjects evaluated for systemic carnitine deficiency. Witryna1. Organic cation transporters (OCTs) play an important role in drug safety and efficacy. Protoberberine alkaloids are ubiquitous organic cations or weak bases with remarkable biological actives. This study was to elucidate the potential interaction of alkaloids (coptisine, jatrorrhizine, epiberberine, berberrubine, palmatine and … epinephrine effects on kidneys