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Organic cation/carnitine transporter

Witryna26 mar 2013 · Major functional clusters for Up-Ex RAGs were glycosaminoglycan binding, cell migration, inorganic cation hemostasis, regulation of phosphorylation, regulation of apoptosis. Down-Nd RAGs were found in the clusters annotated as calcium binding region, domain EF hand, and mitosis. Witryna2 kwi 2014 · The world is getting more complex and interconnected. Increasingly, problem-solving requires knowledge and skills from different expertises. Correspondingly, computational sciences, in particular machine learning and big-data analytic have been rapidly developing to accommodate the need to comprehend operations and …

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Witryna14 lip 2006 · Carnitine is a zwitterion essential for the {beta}-oxidation of fatty acids. We report novel localization of the organic cation/carnitine transporter, OCTN1, to mitochondria. We made GFP- and RFP-human OCTN1 cDNA constructs and showed expression of hOCTN1 in several transfected mammalian cell lines. Witryna8 godz. temu · Organic cation transporter 2 (OCT2) is mainly responsible for the renal secretion of various cationic drugs, closely associated with drug-induced acute kidney injury (AKI). Screening and identifying potent OCT2 inhibitors with little toxicity in natural products in reducing OCT2-mediated AKI is of great value. Flavonoids are enriched in … epinephrine effect on alpha 2 receptors https://mayaraguimaraes.com

Different Involvement of Promoter Methylation in the Expression …

WitrynaThe high-affinity OCTN2 (SLC22A5 gene) carnitine transporter plays a key role in a carnitine homeostasis [4, 10]. It is highly ex-pressed in the heart, muscle and kidney and operate a sodium-de-pendent transport of carnitine and a sodium-independent organic cation transport. A defect in the OCTN2 carnitine transporter cause primary … WitrynaReferences: Amat di San Filippo C et al. Tyrosine residues affecting sodium stimulation of carnitine transport in the OCTN2 carnitine/organic cation transporter. J Biol Chem. 2004; 279(8):7247-53. Li F et al. Molecular spectrum of SLC22A5 (OCTN2) gene mutations detected in 143 subjects evaluated for systemic carnitine deficiency. Witryna1. Organic cation transporters (OCTs) play an important role in drug safety and efficacy. Protoberberine alkaloids are ubiquitous organic cations or weak bases with remarkable biological actives. This study was to elucidate the potential interaction of alkaloids (coptisine, jatrorrhizine, epiberberine, berberrubine, palmatine and … epinephrine effects on kidneys

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Organic cation/carnitine transporter

NM_003060.4(SLC22A5):c.1345T>G (p.Tyr449Asp) AND not provided

WitrynaPharmaceutics 2013, 5 473 identified. The data obtained indicate proteoliposomes as a novel and potentially important tool in drug discovery. Keywords: proteoliposomes; transport; drugs; xenobiotics; reconstitution; drug discovery Abbreviations: OCTN, Organic Cation Transporter Novel; ASCT2, Alanine, Serine, Cysteine, OCTN, … Witryna25 kwi 2013 · This review article summarizes the main treatments for chronic obstructive pulmonary disease, their mechanisms, and the key evidence from trials supporting their use. Drug classes covered were short acting beta agonists (SABA), short acting muscarinic antagonists (SAMA), long acting beta agonists (LABA), long acting …

Organic cation/carnitine transporter

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Witryna15 lut 2024 · The Carnitine-Acylcarnitine Carrier is a member of the mitochondrial Solute Carrier Family 25 (SLC25), known as SLC25A20, involved in the electroneutral exchange of acylcarnitine and carnitine across the inner mitochondrial membrane. It acts as a master regulator of fatty acids β-oxidation and is known to be involved in … WitrynaFunctional Genetic Variation in the Basal Promoter of the Organic Cation/Carnitine Transporters OCTN1 (SLC22A4) and OCTN2 (SLC22A5) Journal of Pharmacology and Experimental Therapeutics, PMID ...

Witryna16 wrz 2024 · The organic cation transporters 1, 2, and 3 (OCT1-3), encoded by the SLC22A1-3 genes, as well as the organic cation/carnitine transporter 1 and 2 (OCTN1 and N2), encoded by the SLC22A4 and SLC22A5 genes have been shown to transport platinum derivatives in vitro (Yonezawa et al., 2006; Filipski et al., 2009; Jong et al., … Witryna9 cze 2010 · The mycotoxin, ochratoxin A (OTA), is thought to be responsible for Balkan endemic nephropathy. OTA accumulates in several tissues, especially in the kidneys and liver. The excretion of OTA into urine is thought to be mainly by tubular secretion, presumably via the organic anion transport system. Recently, several families of …

WitrynaEnter the email address you signed up with and we'll email you a reset link. Witryna16 paź 2013 · Organic cation/carnitine transporter 2 (OCTN2) is responsible for the cellular uptake of the antineoplastic agent, oxaliplatin. Epigenetic modification is a possible mechanism of altered drug-transporter expression in cancers, leading to altered efficacy of chemotherapeutic drugs. However, the mechanisms governing OCTN2 …

Witryna1 sty 2000 · OCTN2 is an organic cation/carnitine transporter that is responsible for Na(+)-coupled transport of carnitine in the kidney and other tissues. We investigated the interaction of several beta-lactam antibiotics with OCTN2 using human cell lines that express the transporter constitutively as well as using cloned human and rat …

WitrynaSeveral SLC22 transporters in the human kidney and other tissues are thought to regulate endogenous small antioxidant molecules such as uric acid, ergothioneine, … epinephrine effect on preload and afterloadepinephrine effect on renal perfusionWitryna24 paź 2024 · The organic cation/carnitine transporter novel 1 and 2 (OCTN1 and N2) and the organic cation transporter 6 (OCT6) are encoded by the SLC22A4, - 5, and - 16, respectively . Other members of the human SLC22 family comprise eight anion transporters (OATs), one urate transporter (URAT1), and fourteen orphan proteins, … epinephrine effect on respiratory systemWitrynaInteractions between genetic and environmental factors, like exposure to stress, have an important role in the pathogenesis of mood-related psychiatric disorders, such as major depressive disorder. The polyspecific organic cation transporters (OCTs) were shown previously to be sensitive to the stress hormone corticosterone in vitro, suggesting … driverobject- majorfunctionWitryna20 cze 2003 · Spermatozoan maturation, motility, and fertility are, in part, dependent upon the progressive increase in epididymal and spermatozoal carnitine, critical for … epinephrine effects on the heartWitrynaL-Carnitine and ALCAR are absorbed in the intestines (jejunum) mostly by the organic cation transporter 2 (OCTN2)[50][51] which is a sodium dependent transporter.[39] This transporters takes up L-carnitine molecules, and while ALCAR needs to be deacetylated (removal of the acetyl group) prior to absorption it can readily be … driver of blackkklansman crossword clueWitryna8 godz. temu · Organic cation transporter 2 (OCT2) is mainly responsible for the renal secretion of various cationic drugs, closely associated with drug-induced acute kidney … epinephrine emotions