Pcp4 heart
SpletPCP4 regulates cardiac rhythmicity through modulation of auto-nomic tone. Thus, Pcp4 influences cardiac rhythmicity through both PC autonomous and central mechanisms. … Splet23. jan. 2007 · Functions as a modulator of calcium-binding by calmodulin. Thereby, regulates calmodulin activity and the different processes it controls ( PubMed: 19106096, PubMed: 23204517, PubMed: 27876793 ). For instance, may play a role in neuronal differentiation through activation of calmodulin-dependent kinase signaling pathways ( …
Pcp4 heart
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Splet10. maj 2024 · An autosomal dominant form of long QT syndrome, a heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy. ... Splet01. okt. 2011 · Purkinje cell protein 4 (PCP4), also called brain-specific polypeptide 19 (PEP19), is a neurospecific, small calmodulin-binding protein that binds both calcium-free and calcium-binding calmodulin...
Splet05. okt. 2024 · The SLC39A12 gene encodes the zinc transporter protein ZIP12, which is expressed across many tissues and is highly abundant in the vertebrate nervous system. As a zinc transporter, ZIP12 functions to transport zinc across cellular membranes, including cellular zinc influx across the plasma membrane. Splet08. okt. 2014 · Pcp4-null mice also displayed profound autonomic dysregulation and arrhythmic behavior in vivo. Together, these results demonstrate that PCP4 regulates …
Splet05. apr. 2024 · Structurally, the mammalian heart is divided into four chambers—the right and left atria and the right and left ventricles—together with components of the conduction system that ensure contraction of cardiac muscle ().Rhythmic contraction and relaxation of the heart ensures proper supply of blood and nutrients throughout the body. SpletPCP4. Purkinje cell protein 4 is a protein that in humans is encoded by the PCP4 gene. [5] [6] [7] Also known as PEP-19, PCP4 is a 7.6 kDa protein with an IQ-motif that binds to calmodulin (CaM). [8] PCP4 is abundant in Purkinje cells of the cerebellum, and plays an important role in synaptic plasticity. [8] [9]
SpletPcp4-null hearts. However, in keeping with PCP4’s putative nega-tive regulatory role, expression of activated pCaMKII was markedly increased in the Purkinje fiber network of Pcp4-null mice compared with controls (Figure 3, B and C). As predicted, based on the lack of PCP4 expression in VMs, this effect was specific for PCs and
SpletSingle cell type specificityi. The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The … c 抽象类Splet05. feb. 2024 · The early detection of heart disease—and your overall health—are helped by establishing a relationship with a primary care provider (PCP) and getting regular … c 指定設備導入事業 補助金額Splet08. jul. 2024 · PCP4/PEP19 is a differentiation maker of Purkinje cells, where it functions as an antiapoptotic factor. Cerebral neuronal cells also express PCP4/PEP19, which may be related to neuronal cell... c 拓展库Splet09. okt. 2014 · Cardiovascular scientists in the USA have identified in mouse models a protein known as Purkinje cell protein-4 (Pcp4) as a regulator of the heart’s rhythm. … c 指定地址数据SpletPcp4-null mice also displayed profound autonomic dysregulation and arrhythmic behavior in vivo. Together, these results demonstrate that PCP4 regulates cardiac excitability … c 指定位取反Splet24. jun. 2024 · Human Positive Coactivator 4 (PC4) is a multifaceted chromatin protein involved in diverse cellular processes including genome organization, transcription … c 指定設備導入事業 補助金Splet26. sep. 2024 · PCP4 regulates cardiac excitability through both Purkinje cell-autonomous and central mechanisms. The PCP4 immunostaining-delineated CA2 neurons have … c 指定初始化