2024 Trps1 breast

Trps1 breast

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August undefined, 2024

WebApr 3, 2024 · Of the five markers compared, TRPS1 seems the most sensitive marker for the mammary origin of CK5-expressing TNBCs, and has a place in breast marker panels. The lack of oestrogen receptor, progesterone receptor and human epidermal growth factor receptor-2 expression in breast cancer (BC) is the basis for the categorization of the … WebJun 14, 2011 · Consistent with this, lower abundance of TRPS1 is a poor prognostic marker in breast cancer . The defects associated with TRPS1 mutation ( 31 ) are indicative of a …

TRPS1 transcriptional repressor GATA binding 1 [ (human)]

WebMar 1, 2024 · TRPS1 has been recently demonstrated as a highly sensitive and specific marker for breast carcinomas. To further explore TRPS1's utility in breast carcinoma, we … WebMar 1, 2024 · TRPS1 Breast tumor Tumor marker 1. Introduction Phyllodes tumor (PT) is a biphasic neoplasm containing both epithelial and stromal components with a characteristic intracanalicular architecture showing leaf-like stromal fronds capped by an epithelial lining. PTs are classified as benign, borderline, or malignant [1, 2 ]. brindley park ashbourne

TRPS1 expression in cytokeratin 5 expressing triple negative breast …

WebAug 2, 2024 · TRPS1 regulates HDAC2 protein level by stabilizing HDAC2 in ubiquitin-dependent proteasomal degradation (UDPD) Analysis of TRPS1 interactome had … WebNov 18, 2024 · TRPS1 is a sensitive and specific marker for metastatic breast cancer in serous effusion cell-block specimens. It shows superior sensitivity and specificity compared with GATA3, especially in the TNBC setting and for excluding urothelial carcinoma. CONFLICTS OF INTEREST The authors made no disclosures. WebTCGA data indicated that the (TRPS1) is a specific gene for breast carcinoma across 31 solid tumor types, including all 4 subtypes of Breast Carcinoma such as ER/PR-positive luminal A and B types, HER2-positive type, and basal-type/TNBC. TRPS1 produced no or little expression in Lung, Pancreatic, Colon, or Gastric Adenocarcinomas, Urothelial, Renal, or … brindley pantomime

TRPS1 Expression in Breast Carcinomas - LWW

WebApr 1, 2024 · As shown in Fig. 1, a high mRNA level of TRPS1 was observed in breast carcinoma only, among the 31 types of solid tumors; moreover, the mRNA level of TRPS1 … WebTRPS1 has been recently demonstrated as a highly sensitive and specific marker for breast carcinomas. To further explore TRPS1’s utility in breast carcinoma, we systematically … can you plant potatoes without eyesWebTRPS1 is commonly amplified in breast cancer, which suggests that restrained YAP activity favours tumour growth. High TRPS1 activity is associated with decreased YAP activity and leads to decreased frequency of tumour-infiltrating immune cells. Our study uncovers TRPS1 as an epigenetic regulator of YAP activity in breast cancer. can you plant potted mums in november

"WebBone is a frequently implicated organ in metastatic breast cancer, and approximately 70% of metastatic breast cancer patients suffer from bone metastases 68. miR-30 family members are involved in breast cancer bone metastases, but their roles remain controversial. Some scholars believe that miR-30 family members employ multiple mechanisms to ... " - Trps1 breast

Trps1 breast

TRPS1 Expression in Breast Carcinomas - LWW

WebThe association between YAP1 and TRPS1 was primarily clarified by Elster et al, who suggested that YAP1 was downregulated, while TRPS1 was commonly amplified in breast cancer, and high TRPS1 activity was associated with decreased YAP1 activity, leading to decreased frequency of tumor-infiltrating immune cells. 15 Therefore, the present study ... WebIn the current study, through TCGA data mining we identified trichorhinophalangeal syndrome type 1 (TRPS1) as a specific gene for breast carcinoma across 31 solid tumor types. Moreover, high mRNA level of TRPS1 was found in all four subtypes of breast carcinoma including ER/PR-positive luminal A and B types, HER2-positive type, and basal …

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WebExpression of TRPS1 (GC79, LGCR) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers. ... Moderate to strong nuclear positivity was observed in all breast cancers and several cases of ovarian, lung, skin and cervical cancer. Most remaining cancer tissues showed weak cytoplasmic positivity or ... WebNov 11, 2024 · In this study, overexpression of lncRNA178030.2 significantly attenuated the inhibitory effect of 1 μM paclitaxel in cell proliferation of MDA-MB-231, while knockdown of lncRNA178030.2 had an opposite effect, suggesting that lncRNA178030.2 mediated the process of paclitaxel resistance of breast cancer cells. TRPS1 is a newly discovered …

WebTRPS1 gene was responsible for most of the TRPS phenotype; Data show that co-silencing of tricho-rhino-phalangeal-syndrome (TRPS1) and cathepsin D (Cath-D) in breast cancer … WebFeb 15, 2024 · TRPS1 is a GATA-like transcription factor, which functions as a transcriptional repressor or activator, depending on cell type, stage of development, or pathological conditions. Based on this assumption, we explored additional roles of TRPS1 in tumor progression.

WebMay 5, 2008 · Individuals with TRPS1 may also exhibit other physical abnormalities including abnormal prominence of the breast bone (pectus carinatum), an unusual “wing-like” shape … WebMar 11, 2016 · TRPS1 was frequently down-regulated in high-metastatic cancer cell lines from the breast, colon and nasopharynx. Silencing of TRPS1 stimulated epithelial–mesenchymal transition (EMT), migration and invasion in vitro and metastasis in vivo , while TRPS1 over-expression exhibited the opposite effects.

WebOct 3, 2024 · In the current study, through TCGA data mining we identified trichorhinophalangeal syndrome type 1 (TRPS1) as a specific gene for breast carcinoma across 31 solid tumor types. Moreover, high...

WebOct 30, 2024 · TRPS1 as Both an Activator and a Repressor of Transcription in Breast Cancer Because TRPS1 is a TF that may directly regulate genes required for G2-M progression and survival in breast cancer cells, we performed RNA-seq of HCC3153 and SUM159 cell lines 3, 4, and 5 days after inducing TRPS1 knockdown. brindley outer banks nc brindley park square ashbourneWebTRPS1抑制SOX2在乳腺癌细胞干性维持和肿瘤发生起始的转录调控机制研究.pdf brindley park property groupWebJun 14, 2011 · The transcription factor FOSL1 (also known as Fra-1), which is found in basal-like breast cancers but not in the luminal subtype, stimulated the transcription of miR-221/222, and the abundance of these miRNAs decreased with inhibition of the epidermal growth factor receptor (EGFR) or MEK (mitogen-activated or extracellular … brindley penelope phdWebTRPS1 Is a Lineage-Specific Transcriptional Dependency in Breast Cancer Highlights • Poorly differentiated human cancers have limited shared epigenomic dependencies • TRPS1 is a breast lineage-specific transcriptional dependency • TRPS1 is required for normal mitosis by directly regulating genes in G2-M • can you plant potatoes without sproutsWebSep 4, 2024 · Results. PVT1 expression was upregulated in breast cancer tissues and cell lines. In addition, PVT1 silencing inhibited breast cancer cell growth and motility, while … can you plant pond plants in winterWebAmong non-breast tumors, TRPS1 is only expressed in some cases of lung squamous cell carcinoma, urothelial carcinoma (2%), and ovarian adenocarcinoma. Therefore, TRPS1 … can you plant raw sunflower seeds